Pesticides - Agricultural Pesticide Use Regulations Pesticides can be hazardous to workers if they are exposed to them through the skin, eyes, mouth, or the air we breathe. Agricultural pesticide handlers should get the proper certificates, permits, and training to use pesticides safely, correctly, and according to the requirements of the law. The California Department of Pesticide Regulation (DPR) governs pesticide use in agricultural operations and classifies pesticides as “general” or “restricted” use. Workers must be certified to buy, use, or supervise the use of restricted pesticides and usually require a permit from the local to do so. Workers must read and follow...